@Mike: There is no reason to stay away from pulp gaming.
@Rhoderic: Personally I’d never played .45 Adventure. So, I am not aware of their mechanics. But my fantasy campaign is in an early stage. I have done some research for stuff like scenery, concepts for NPCs and random encounters, game mechanics for certain scenarios and all that stuff. For example, while watching a movie, I came up with the idea of a “light/darkness dynamic”, where certain groups or characters gain advantages/disadvantages while operating in the light or in the shadows. I also came up with the idea to include “sidequests”, so that the league could gain 1 or 2 extra plot points in certain games. But of course serious playtesting will be needed in regard of balancing the whole thing.
@Don Glewwe: I totally agree. I guess there is no setting, which can’t be played with pulp alley.