Straight on the nose is the most effective way to take out bombers, even those heavy B17Gs with nose mounted duel .50, you are closing so fast they usually can’t get a beat on you. The problem is.
1. To get in a position to do a head on attack.
2. After the first attack, you have to catch up with the bombers fly past then several km. Then do another attacks. This means if the bombers are close to their target, you might only have time for one attack.
3. If bombers have escorts, you can can just forget about a second pass(granted this is true for any attack direction)