My leagues range from heroes with pluck and skill to mystics.
The Investigators are all pretty much normal humans. Omar and P.D. have minor abilities that border on the paranormal.
The Gold Lama is full on mystic arts from the ancient East.
Zakaar and his band are pure Lost World fantasy with an undead Lizardman prince and a boy with an ancient Atlantean magic stone.
The major advantage I find in Pulp Alley is that the abilities are, for the most part, open thematically. One of our leagues features an evil scientist who has as a Shooting stat and Mind blast all themed to his Mentallo Sphere – a psionic weapon.